Honokiol

• Description:

  Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4].

• Product Name Alternative:

  NSC 293100

• UNSPSC:

  12352005

• Hazard Statement:

  H318, H410

• Target:

  Akt; Autophagy; ERK; HCV

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Autophagy; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/honokiol.html

• Purity:

  99.94

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  OC1=C (CC=C) C=C (C2=CC (CC=C) =CC=C2O) C=C1

• Molecular Formula:

  C18H18O2

• Molecular Weight:

  266.33

• Precautions:

  H318, H410

• References & Citations:

  [1]Chang KH, et al. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013 Nov;6 (5) :1435-1438.|[2]Godugu C, et al. Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC) . Colloids Surf B Biointerfaces. 2017 Jan 23;153:208-219|[3]Lee TY, et al. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep. 2017 Jan 5;7:40002|[4]Zhai H, et al. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2) . Eur J Pharmacol. 2005 Jun 1;516 (2) :112-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 3

• Isoform:

  ERK1; ERK2

• CAS Number:

  35354-74-6