Maropitant

• Description :

  Maropitant is an orally active NK1 receptor antagonist. Maropitant prevents vomiting and inhibits ulcerative dermatitis[1][2].

• CAS Number :

  [147116-67-4]

• UNSPSC :

  12352005

• Hazard Statement :

  H317, H372, H410

• Target :

  Neurokinin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Maropitant.html

• Concentration :

  10mM

• Purity :

  99.52

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC(C)(C)C1=CC=C(OC)C(CN[C@@H]2[C@H](C(C3=CC=CC=C3)C4=CC=CC=C4)N5CCC2CC5)=C1

• Molecular Formula :

  C32H40N2O

• Molecular Weight :

  468.67

• Precautions :

  H317, H372, H410

• References & Citations :

  [1]Hay Kraus BL. Efficacy of orally administered maropitant citrate in preventing vomiting associated with hydromorphone administration in dogs. J Am Vet Med Assoc. 2014 May 15;244 (10) :1164-9.|[2]Williams-Fritze MJ, et al. Maropitant citrate for treatment of ulcerative dermatitis in mice with a C57BL/6 background. J Am Assoc Lab Anim Sci. 2011 Mar;50 (2) :221-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NK1R