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Neoaureothin

CAT: 0804-HY-N8504-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8504-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50=13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50=1.75 nM) . Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s=34.3, 47, and 37.2 μg/mL, respectively) . It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus.
CAS Number
59795-94-7
Product Name Alternative
NSC 260179; Spectinabilin
UNSPSC
12352200
Target
Bacterial
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/neoaureothin.html
Smiles
CC(C1=O)=C([C@@](OC/2)([H])CC2=C\C(C)=C\C(C)=C\C(C)=C\C(C=C3)=CC=C3[N+]([O-])=O)OC(OC)=C1C
Molecular Formula
C28H31NO6
Molecular Weight
477.55
References & Citations
[1]Kawamura, et al. Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomyces sp. MK756-CF1. J. Antibiot. (Tokyo) 63 (10), 601-605 (2010) .
Shipping Conditions
Room temperature
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

Alternative Products

CatalogName
T35668Neoaureothin
N1011-40Neoaureothin (Spectabilin)

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