Antisauvagine-30

• Description:

  Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively) . Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49) . Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  3650.29

• Molecular Formula:

  C161H274N48O46S

• Notes:

  Research use only, not for human use.

• Receptor:

  ——

• CAS Number:

  220673-95-0