K 41498

• Description:

  Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively) . Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  3632.26

• Molecular Formula:

  C162H276N48O46

• Notes:

  Research use only, not for human use.

• Receptor:

  ——

• CAS Number:

  434938-41-7