Obtustatin

• Description:

  Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen) . Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  4393.07

• Molecular Formula:

  C184H284N52O57S8

• Notes:

  Research use only, not for human use.

• Receptor:

  ——