ZIP

• Description :

  Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

• Stability :

  ≥ 2 years

• Purity :

  >98% (HPLC)

• Weight :

  1928.4

• Molecular Formula :

  C90H154N30O17

• Notes :

  Research use only, not for human use.

• Receptor :

  ——

• CAS Number :

  863987-12-6