Products for Research Use Only
RegisterLogin

BLU-945

CAT: 1410-M37656-05Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1410-M37656-05Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs) . BLU-945 inhibits EGFR phosphorylation in EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S mutant cell lines. BLU-945 can be used in lung cancer research, including non-small cell lung cancer (NSCLC) .
CAS Number
2660250-10-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
556.7
Molecular Formula
C28H37FN6O3S
Notes
Research use only, not for human use.
Receptor
EGFR

Chemical Information

Tigozertinib

Tigozertinib (BLU-945) is currently under investigation in clinical trial NCT04862780 (Phase 1/​2 Study Targeting EGFR Resistance Mechanisms in NSCLC) for the treatment of NSCLC.

CAS Number2660250-10-0
PubChem CID156538665
IUPAC NameN-[2-[(3S,4R)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]-8-[(2R,3S)-2-methyl-3-(methylsulfonylmethyl)azetidin-1-yl]-5-propan-2-ylisoquinolin-3-amine
Molecular FormulaC28H37FN6O3S
Molecular Weight556.7
XLogP4.6
Topological Polar Surface Area109
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Heavy Atom Count39
Formal Charge0
Complexity921
SMILES
C[C@@H]1[C@H](CN1C2=C3C=NC(=CC3=C(C=C2)C(C)C)NC4=NC(=NC=C4)N5CC[C@H]([C@H](C5)F)OC)CS(=O)(=O)C
InChI
InChI=1S/C28H37FN6O3S/c1-17(2)20-6-7-24(35-14-19(18(35)3)16-39(5,36)37)22-13-31-27(12-21(20)22)32-26-8-10-30-28(33-26)34-11-9-25(38-4)23(29)15-34/h6-8,10,12-13,17-19,23,25H,9,11,14-16H2,1-5H3,(H,30,31,32,33)/t18-,19-,23+,25-/m1/s1
InChIKey
LIMFPAAAIVQRRD-BCGVJQADSA-N
Chemical Structure
2D Structure
2D structure of Tigozertinib
CAS: 2660250-10-0
CID: 156538665
Formula: C28H37FN6O3S
MW: 556.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight556.7
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass556.26318840
Monoisotopic Mass556.26318840
Topological Polar Surface Area109 Ų
Heavy Atom Count39
Formal Charge0
Complexity921
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
M28772-01AMP-945
M12606-01BLU-554
M37619-01BLU-263
M21181-01Blu-782
M37524-01BLU-222
M11250GS-9451
M14013-01Evans blue
M24531-01Calcein Blue
M22848-01Diphenyl Blue
M21733-01Thiazolyl Blue

Alternative Products

CatalogName
BA6329-1BLU-945
AR-B07450-01BLU-945-13C-d5
AR-B07451-01BLU-945-13C-d6
AR-B07452-01N-Nitroso BLU-945
A24033-50BLU-945 (ZL-2313) 50mg
A24033-10BLU-945 (ZL-2313) 10mg
A24033-100BLU-945 (ZL-2313) 100mg
A24033-5BLU-945 (ZL-2313) 5mg
GL2252-25mgBLZ-945

Popular Products