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Miclxin

CAT: 1410-M36523-07Size: 200 mgDry Ice: NoHazardous: No
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CAT#:1410-M36523-07Size:200 mg
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Description
Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60.
CAS Number
2494198-61-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
441.52
Molecular Formula
C26H27N5O2
Notes
Research use only, not for human use.
Receptor
Wnt/beta-catenin

Chemical Information

Miclxin
CAS Number2494198-61-5
PubChem CID155891739
IUPAC Name7-methoxy-N-[(3-methoxyphenyl)methyl]-2-(3-pyridin-3-ylpyrrolidin-1-yl)quinazolin-4-amine
Molecular FormulaC26H27N5O2
Molecular Weight441.5
XLogP4.6
Topological Polar Surface Area72.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count33
Formal Charge0
Complexity609
SMILES
COC1=CC2=C(C=C1)C(=NC(=N2)N3CCC(C3)C4=CN=CC=C4)NCC5=CC(=CC=C5)OC
InChI
InChI=1S/C26H27N5O2/c1-32-21-7-3-5-18(13-21)15-28-25-23-9-8-22(33-2)14-24(23)29-26(30-25)31-12-10-20(17-31)19-6-4-11-27-16-19/h3-9,11,13-14,16,20H,10,12,15,17H2,1-2H3,(H,28,29,30)
InChIKey
OXSWPFXQCLRTCF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Miclxin
CAS: 2494198-61-5
CID: 155891739
Formula: C26H27N5O2
MW: 441.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight441.5
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass441.21647512
Monoisotopic Mass441.21647512
Topological Polar Surface Area72.4 Ų
Heavy Atom Count33
Formal Charge0
Complexity609
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA9144-50Miclxin

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