BI-0474

• Description:

  BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model. activity.BI-0474 can be used for cancer research.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  587.74

• Molecular Formula:

  C30H37N9O2S

• Notes:

  Research use only, not for human use.

• Receptor:

  Kras

• CAS Number:

  2750570-55-7