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KW-2450 free base

CAT: 1410-M36254-01Size: 1 EachDry Ice: NoHazardous: No
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CAT#:1410-M36254-01Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.
CAS Number
904899-25-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
515.63
Molecular Formula
C28H29N5O3S
Notes
Research use only, not for human use.
Receptor
IGF-1R

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