RP-6685

• Description:

  RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Polθ. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model .

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  497.37

• Molecular Formula:

  C22H14F7N5O

• Notes:

  Research use only, not for human use.

• Receptor:

  DNA/RNA Synthesis

• CAS Number:

  2832047-80-8