GNE-064

• Description:

  GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  327.38

• Molecular Formula:

  C17H21N5O2

• Notes:

  Research use only, not for human use.

• Receptor:

  Epigenetic Reader Domain

• CAS Number:

  1997321-20-6