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GP 1a

CAT: 1410-M35265-01Size: 1 EachDry Ice: NoHazardous: No
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Description
GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and increases P-ERK1/2 expression in HL-60 cells in vitro. GP 1a is beneficial for skin wound healing. GP 1a inhibits inflammation and fibrogenesis while promoting epithelial re-formation.
CAS Number
511532-96-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
441.35
Molecular Formula
C23H22Cl2N4O
Notes
Research use only, not for human use.
Receptor
Cannabinoid Receptor | PERK

Chemical Information

N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide

1-(2,4-dichlorophenyl)-6-methyl-N-(1-piperidinyl)-4H-indeno[1,2-c]pyrazole-3-carboxamide is a member of pyrazoles and a ring assembly.

CAS Number511532-96-0
PubChem CID10252734
IUPAC Name1-(2,4-dichlorophenyl)-6-methyl-N-piperidin-1-yl-4H-indeno[2,1-d]pyrazole-3-carboxamide
Molecular FormulaC23H22Cl2N4O
Molecular Weight441.3
XLogP5.9
Topological Polar Surface Area50.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count30
Formal Charge0
Complexity630
SMILES
CC1=CC2=C(C=C1)C3=C(C2)C(=NN3C4=C(C=C(C=C4)Cl)Cl)C(=O)NN5CCCCC5
InChI
InChI=1S/C23H22Cl2N4O/c1-14-5-7-17-15(11-14)12-18-21(23(30)27-28-9-3-2-4-10-28)26-29(22(17)18)20-8-6-16(24)13-19(20)25/h5-8,11,13H,2-4,9-10,12H2,1H3,(H,27,30)
InChIKey
FNOMTMVRTBHRET-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide
CAS: 511532-96-0
CID: 10252734
Formula: C23H22Cl2N4O
MW: 441.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight441.3
XLogP35.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass440.1170667
Monoisotopic Mass440.1170667
Topological Polar Surface Area50.2 Ų
Heavy Atom Count30
Formal Charge0
Complexity630
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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