EM 163

• Description:

  EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB) . EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1β on chemically induced long-term potentiation (LTP) -triggered protein synthesis.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  849.88

• Molecular Formula:

  C44H60IN5O4

• Notes:

  Research use only, not for human use.

• Receptor:

  MyD88 | p38 MAPK | IL Receptor

• CAS Number:

  1206480-93-4