LC-2

• Description:

  LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recruits the E3 ligase, VH, to induce a rapid and sustained degradation of KRAS G12C. LC-2 inhibits MAPK signaling in pure and heterozygous KRAS G12C cell lines.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  1132.78

• Molecular Formula:

  C59H71ClFN11O7S

• Notes:

  Research use only, not for human use.

• Receptor:

  PROTACs

• CAS Number:

  2502156-03-6