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Erastin2

CAT: 1410-M34807-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M34807-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Erastin2 is a ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter. It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM) and induces cell death in HAP1 cells at 5 µM, an effect blocked by ferrostatin-1 or deferoxamine. Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect blocked by β-mercaptoethanol (EC50 > 20 µM) . Additionally, it increases lipid peroxidation in HT-1080 cells at 1 µM.
CAS Number
1695533-44-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
623.14
Molecular Formula
C36H35ClN4O4
Notes
Research use only, not for human use.
Receptor
Ferroptosis

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