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MC1742

CAT: 1410-M34786-01Size: 1 EachDry Ice: NoHazardous: No
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CAT#:1410-M34786-01Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively) .1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9) . MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs) . It increases levels of acetylated histone H3 and acetylated tubulin and induces apoptosis in MG-63 CSCs when used at a concentration of 2 μM. MC1742 also reactivates HIV-1 in JLAT 10.6 latently infected cells (EC50 = 350 nM) .2
CAS Number
1776116-74-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
395.47
Molecular Formula
C21H21N3O3S
Notes
Research use only, not for human use.
Receptor
Others

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CatalogName
BA3134-50MC1742
A24055-50MC1742 50mg
A24055-100MC1742 100mg
A24055-10MC1742 10mg
A24055-5MC1742 5mg

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