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LDN-193189 2HCl

CAT: 1410-M34754-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M34754-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively. LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors ALK2 and ALK3 in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively, and was 200-fold more selective for BMP than for TGF-β.
CAS Number
1435934-00-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
479.4
Molecular Formula
C25H24Cl2N6
Notes
Research use only, not for human use.
Receptor
TGF-beta/Smad | ALK

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