14,15-Dehydro Leukotriene B4

14,15-Dehydro Leukotriene B4

• CAS Number: 114616-11-4
• UNSPSC Description: 14,15-Dehydro Leukotriene B4 (Compound 4) is a LTB4 receptor antagonist. 14,15-Dehydro Leukotriene B4 also has a higher binding affinity for BLT1 with a Ki value of 27 nM and BLT2 with a Ki value of 473 nM. 14,15-Dehydro Leukotriene B4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM[1][2].
• Target Antigen: Leukotriene Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Field of Research: Inflammation/Immunology; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/14-15-dehydro-leukotriene-b4.html
• Smiles: CCCCCC#CC[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
• Molecular Weight: 334.45
• References & Citations: [1]Shimazaki T, et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins. 1990 Apr;39(4):459-67. |[2]Wang S, et al. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. J Biol Chem. 2000 Dec 29;275(52):40686-94.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported