TC-N 22A

• Description:

  TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very low activity against mGlu 1, 2, 3, 5, and 7 receptors in excitation and forward allosteric models (EC50 >10 μM) . TC-N 22A can be used in the study of central nervous system diseases.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  283.35

• Molecular Formula:

  C14H13N5S

• Notes:

  Research use only, not for human use.

• Receptor:

  GluR

• CAS Number:

  1314140-00-5