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MG-115

CAT: 1410-M33748-01Size: 1 EachDry Ice: NoHazardous: No
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Description
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis .
CAS Number
133407-86-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
461.59
Molecular Formula
C25H39N3O5
Notes
Research use only, not for human use.
Receptor
Proteasome

Chemical Information

MG-115

N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester is a peptide.

CAS Number133407-86-0
PubChem CID9868928
IUPAC Namebenzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Molecular FormulaC25H39N3O5
Molecular Weight461.6
XLogP4.4
Topological Polar Surface Area114
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count15
Heavy Atom Count33
Formal Charge0
Complexity617
SMILES
CCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
InChI
InChI=1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
InChIKey
QEJRGURBLQWEOU-FKBYEOEOSA-N
Chemical Structure
2D Structure
2D structure of MG-115
CAS: 133407-86-0
CID: 9868928
Formula: C25H39N3O5
MW: 461.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.6
XLogP34.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count15
Exact Mass461.28897135
Monoisotopic Mass461.28897135
Topological Polar Surface Area114 Ų
Heavy Atom Count33
Formal Charge0
Complexity617
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS5802220MG-115
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A11601-200MG-115 200mg
A11601-50MG-115 50mg
A11601-10MG-115 10mg
A11601-1MG-115 1mg
A11601-100MG-115 100mg
A11601-25MG-115 25mg
A11601-5MG-115 5mg
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