Pladienolide B

• Description:

  Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pre-mRNA splicing and inducing necrosis.Pladienolide B possesses antitumor activity and can be used to study leukemia and lymphoid tumors. Pladienolide B has antitumor activity and can be used to study leukemia and lymphoid tumors.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  536.7

• Molecular Formula:

  C30H48O8

• Notes:

  Research use only, not for human use.

• Receptor:

  Apoptosis

• CAS Number:

  445493-23-2