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CBS9106

CAT: 1410-M33306-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M33306-02Size:5 mg
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Description
CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activity.CBS9106 inhibits CRM1-dependent nuclear export and reduces CRM1 protein levels.CBS9106 inhibits tumor growth and prolongs the survival of mice bearing tumor xenografts.CBS9106 is an inhibitor of CRM1-dependent nuclear export and reduces CRM1 protein levels.
CAS Number
1076235-04-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
419.83
Molecular Formula
C18H21ClF3N3O3
Notes
Research use only, not for human use.
Receptor
CRM1

Chemical Information

Felezonexor

Felezonexor is a small molecule drug. The usage of the INN stem '-nexor' in the name indicates that Felezonexor is a nuclear export inhibitor. Felezonexor is under investigation in clinical trial NCT02667873 (A Trial of a Novel XPO1 Inhibitor in Participants With Advanced Solid Tumors). Felezonexor has a monoisotopic molecular weight of 419.12 Da.

CAS Number1076235-04-5
PubChem CID25103750
IUPAC Name1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-(3,3-dimethylbutoxymethyl)-4-methylpyrrole-2,5-dione
Molecular FormulaC18H21ClF3N3O3
Molecular Weight419.8
XLogP4.6
Topological Polar Surface Area71.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count28
Formal Charge0
Complexity646
SMILES
CC1=C(C(=O)N(C1=O)NC2=NC(=C(C=C2)C(F)(F)F)Cl)COCCC(C)(C)C
InChI
InChI=1S/C18H21ClF3N3O3/c1-10-11(9-28-8-7-17(2,3)4)16(27)25(15(10)26)24-13-6-5-12(14(19)23-13)18(20,21)22/h5-6H,7-9H2,1-4H3,(H,23,24)
InChIKey
CMASLSTVVOYJQY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Felezonexor
CAS: 1076235-04-5
CID: 25103750
Formula: C18H21ClF3N3O3
MW: 419.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight419.8
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass419.1223537
Monoisotopic Mass419.1223537
Topological Polar Surface Area71.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity646
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T14885-01CBS9106
A19643-1CBS9106 1mg
A19643-10CBS9106 10mg
A19643-5CBS9106 5mg
A19643-50CBS9106 50mg
A19643-25CBS9106 25mg

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