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H-89

CAT: 1410-M32956-07Size: 500 mgDry Ice: NoHazardous: No
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CAT#:1410-M32956-07Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H-89 is a selective and potent protein kinase A inhibitor (IC50: 48 nM), a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.
CAS Number
127243-85-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
446.36
Molecular Formula
C20H20BrN3O2S
Notes
Research use only, not for human use.
Receptor
PKA

Chemical Information

protein kinase inhibitor H89

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide is a member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N1-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor. It has a role as an EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor. It is a member of isoquinolines, a sulfonamide, a member of bromobenzenes, a secondary amino compound and an olefinic compound. It is a conjugate base of a N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide(2+).

CAS Number127243-85-0
PubChem CID449241
IUPAC NameN-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide
Molecular FormulaC20H20BrN3O2S
Molecular Weight446.4
XLogP3.5
Topological Polar Surface Area79.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count27
Formal Charge0
Complexity570
SMILES
C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br
InChI
InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
InChIKey
ZKZXNDJNWUTGDK-NSCUHMNNSA-N
Chemical Structure
2D Structure
2D structure of protein kinase inhibitor H89
CAS: 127243-85-0
CID: 449241
Formula: C20H20BrN3O2S
MW: 446.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight446.4
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass445.04596
Monoisotopic Mass445.04596
Topological Polar Surface Area79.5 Ų
Heavy Atom Count27
Formal Charge0
Complexity570
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS131532H 89 (Protein kinase inhibitor H-89; H89; H 89)
T11524-01H-89
MBS386955-01H 89 2HCl
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BUP13153-01H-89 dihydrochloride

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