CHMFL-PI3KD-317

CAT: 1410-M32845-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M32845-01Size:1 g
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Description
CHMFL-PI3KD-317 is a highly potent, selective, and orally active PI3Kδ inhibitor with an IC50 of 6 nM, exhibiting over 10-1500 fold selectivity over other class I, II, and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM), and PI4KIIIB (IC50, 300.2 nM) . It inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells with an EC50 of 4.3 nM and has antiproliferative effects on cancer cells.
CAS Number
2244992-76-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
494.03
Molecular Formula
C21H24ClN5O3S2
Notes
Research use only, not for human use.
Receptor
PI3K | PI4K

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