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GFT505

CAT: 1410-M28578-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M28578-07Size:100 mg
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Description
GFT505 (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
CAS Number
824932-88-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
384.49
Molecular Formula
C22H24O4S
Notes
Research use only, not for human use.
Receptor
——

Chemical Information

2-(2,6-Dimethyl-4-((1E)-3-(4-(methylthio)phenyl)-3-oxo-1-propen-1-yl)phenoxy)-2-methylpropanoic acid

Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR) α and β/δ agonist that works to inhibit bile acid synthesis. On June 10, 2024, elafibranor was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis (PBC). The drug was also approved by the EMA on September 23, 2024.

CAS Number824932-88-9
PubChem CID9864881
IUPAC Name2-[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid
Molecular FormulaC22H24O4S
Molecular Weight384.5
XLogP5.1
Topological Polar Surface Area88.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count27
Formal Charge0
Complexity537
SMILES
CC1=CC(=CC(=C1OC(C)(C)C(=O)O)C)/C=C/C(=O)C2=CC=C(C=C2)SC
InChI
InChI=1S/C22H24O4S/c1-14-12-16(13-15(2)20(14)26-22(3,4)21(24)25)6-11-19(23)17-7-9-18(27-5)10-8-17/h6-13H,1-5H3,(H,24,25)/b11-6+
InChIKey
AFLFKFHDSCQHOL-IZZDOVSWSA-N
Chemical Structure
2D Structure
2D structure of 2-(2,6-Dimethyl-4-((1E)-3-(4-(methylthio)phenyl)-3-oxo-1-propen-1-yl)phenoxy)-2-methylpropanoic acid
CAS: 824932-88-9
CID: 9864881
Formula: C22H24O4S
MW: 384.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight384.5
XLogP35.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass384.13953042
Monoisotopic Mass384.13953042
Topological Polar Surface Area88.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity537
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3617108-01GFT505
MBS131562Elafibranor (GFT505)

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