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CHM-1

CAT: 1410-M27612-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:1410-M27612-05Size:50 mg
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Description
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
CAS Number
154554-41-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
283.258
Molecular Formula
C16H10FNO3
Notes
Research use only, not for human use.
Receptor
Antibiotic|P-glycoprotein

Chemical Information

6-(2-Fluorophenyl)-1,3-dioxolo(4,5-g)quinolin-8(5H)-one

CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity. (MedChemExpress).

CAS Number154554-41-3
PubChem CID375860
IUPAC Name6-(2-fluorophenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one
Molecular FormulaC16H10FNO3
Molecular Weight283.25
XLogP3.1
Topological Polar Surface Area47.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity466
SMILES
C1OC2=C(O1)C=C3C(=C2)C(=O)C=C(N3)C4=CC=CC=C4F
InChI
InChI=1S/C16H10FNO3/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12/h1-7H,8H2,(H,18,19)
InChIKey
ZMYDAPJHGNEFGQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-(2-Fluorophenyl)-1,3-dioxolo(4,5-g)quinolin-8(5H)-one
CAS: 154554-41-3
CID: 375860
Formula: C16H10FNO3
MW: 283.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight283.25
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass283.06447134
Monoisotopic Mass283.06447134
Topological Polar Surface Area47.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity466
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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