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ON 146040

CAT: 1410-M26350-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M26350-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.
CAS Number
1404231-34-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
489.55
Molecular Formula
C24H23N7O3S
Notes
Research use only, not for human use.
Receptor
CB1

Chemical Information

(7Z)-2-[4-(4-Methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one
CAS Number1404231-34-0
PubChem CID73297262
IUPAC Name(7Z)-2-[4-(4-methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one
Molecular FormulaC24H23N7O3S
Molecular Weight489.6
XLogP3.8
Topological Polar Surface Area145
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity784
SMILES
CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C(=N3)S/C(=C\C5=CC=C(C=C5)[N+](=O)[O-])/C(=O)N4
InChI
InChI=1S/C24H23N7O3S/c1-29-10-12-30(13-11-29)18-8-4-17(5-9-18)26-24-25-15-20-23(28-24)35-21(22(32)27-20)14-16-2-6-19(7-3-16)31(33)34/h2-9,14-15H,10-13H2,1H3,(H,27,32)(H,25,26,28)/b21-14-
InChIKey
PKCHFYZACODWAI-STZFKDTASA-N
Chemical Structure
2D Structure
2D structure of (7Z)-2-[4-(4-Methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one
CAS: 1404231-34-0
CID: 73297262
Formula: C24H23N7O3S
MW: 489.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight489.6
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass489.15830879
Monoisotopic Mass489.15830879
Topological Polar Surface Area145 Ų
Heavy Atom Count35
Formal Charge0
Complexity784
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
T12310-01ON 146040
A16266-25ON 146040 25mg
A16266-1ON 146040 1mg
A16266-50ON 146040 50mg
A16266-5ON 146040 5mg
A16266-200ON 146040 200mg
A16266-100ON 146040 100mg
A16266-10ON 146040 10mg

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