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LY2183240

CAT: 1410-M24889-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1410-M24889-02Size:10 mg
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Description
LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM) . LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM) .
CAS Number
874902-19-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
307.35
Molecular Formula
C17H17N5O
Notes
Research use only, not for human use.
Receptor
Autophagy|FAAH

Chemical Information

5-([1,1'-Biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide

LY-2183240 is a member of the class of tetrazoles that is 1H-tetrazole substituted by N,N-dimethylcarbonyl and [biphenyl]-4-ylmethyl groups at positions 1 and 5, respectively. It was developed by Eli Lilly as a potent inhibitor of anandamide re-uptake and fatty acid amide hydrolase, the enzyme responsible for degrading anandamide. It has a role as an anxiolytic drug, an analgesic and an EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor. It is a tertiary carboxamide, a member of biphenyls and a member of tetrazoles.

CAS Number874902-19-9
PubChem CID11507802
IUPAC NameN,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
Molecular FormulaC17H17N5O
Molecular Weight307.35
XLogP3
Topological Polar Surface Area63.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity388
SMILES
CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3
InChI
InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
InChIKey
GZNIYOXWFCDBBJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-([1,1'-Biphenyl]-4-ylmethyl)-N,N-dimethyl-1H-tetrazole-1-carboxamide
CAS: 874902-19-9
CID: 11507802
Formula: C17H17N5O
MW: 307.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight307.35
XLogP33
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass307.14331018
Monoisotopic Mass307.14331018
Topological Polar Surface Area63.9 Ų
Heavy Atom Count23
Formal Charge0
Complexity388
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A3571-5.1LY2183240

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