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TMN355

CAT: 1410-M22935-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:1410-M22935-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion, and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
CAS Number
1186372-20-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
380.8
Molecular Formula
C21H14ClFN2O2
Notes
Research use only, not for human use.
Receptor
Cyclophilin A

Chemical Information

2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
CAS Number1186372-20-2
PubChem CID44249042
IUPAC Name2-chloro-N-(9H-fluoren-9-ylcarbamoyl)-6-fluorobenzamide
Molecular FormulaC21H14ClFN2O2
Molecular Weight380.8
XLogP5
Topological Polar Surface Area58.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count27
Formal Charge0
Complexity552
SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)NC(=O)NC(=O)C4=C(C=CC=C4Cl)F
InChI
InChI=1S/C21H14ClFN2O2/c22-16-10-5-11-17(23)18(16)20(26)25-21(27)24-19-14-8-3-1-6-12(14)13-7-2-4-9-15(13)19/h1-11,19H,(H2,24,25,26,27)
InChIKey
SFNLLCUAISZNRV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
CAS: 1186372-20-2
CID: 44249042
Formula: C21H14ClFN2O2
MW: 380.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight380.8
XLogP35
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass380.0727835
Monoisotopic Mass380.0727835
Topological Polar Surface Area58.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity552
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5764632TMN355
A22697-1TMN355 1mg
A22697-25TMN355 25mg
A22697-100TMN355 100mg
A22697-10TMN355 10mg
A22697-500TMN355 500mg
A22697-50TMN355 50mg
A22697-5TMN355 5mg
A22697-2TMN355 2mg
A22697-10mM-DTMN355 10mM * 1mL in DMSO

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