FIDAS-5

• Description :

  FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities. FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.FIDAS-5 induces the expression of cell cycle inhibitor, p21WAF1/CIP1. FIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells.

• CAS Number :

  1391934-98-7

• Stability :

  ≥ 2 years

• Purity :

  >98% (HPLC)

• Weight :

  261.72

• Molecular Formula :

  C15H13ClFN

• Notes :

  Research use only, not for human use.

• Receptor :

  MAT2A