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DSS Crosslinker

CAT: 1410-M22922-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M22922-01Size:100 mg
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Description
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters at both ends of an 8-atom (11.4 angstrom) spacer arm that are used to conjugate proteins.
CAS Number
68528-80-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
368.34
Molecular Formula
C16H20N2O8
Notes
Research use only, not for human use.
Receptor
Non-cleavable

Chemical Information

N-Hydroxysuccinimide suberic acid ester

Disuccinimidyl suberate is a N-hydroxysuccinimide ester resulting from the formal condensation of the two carboxy groups of suberic acid with the hydroxy group of 1-hydroxypyrrolidine-2,5-dione. It is a noncleavable and membrane permeable crosslinker. It has a role as a cross-linking reagent. It is a diester and a N-hydroxysuccinimide ester. It is functionally related to a suberic acid.

CAS Number68528-80-3
PubChem CID100658
IUPAC Namebis(2,5-dioxopyrrolidin-1-yl) octanedioate
Molecular FormulaC16H20N2O8
Molecular Weight368.34
XLogP-0.1
Topological Polar Surface Area127
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count11
Heavy Atom Count26
Formal Charge0
Complexity544
SMILES
C1CC(=O)N(C1=O)OC(=O)CCCCCCC(=O)ON2C(=O)CCC2=O
InChI
InChI=1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2
InChIKey
ZWIBGKZDAWNIFC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Hydroxysuccinimide suberic acid ester
CAS: 68528-80-3
CID: 100658
Formula: C16H20N2O8
MW: 368.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.34
XLogP3-0.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count11
Exact Mass368.12196560
Monoisotopic Mass368.12196560
Topological Polar Surface Area127 Ų
Heavy Atom Count26
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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