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Kurarinone

CAT: 1410-M22861-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M22861-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Kurarinone, a flavanoid derived from shrub Sophora flavescens, Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4 (+) T-cell differentiation and the overall immune response.
CAS Number
34981-26-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
438.52
Molecular Formula
C26H30O6
Notes
Research use only, not for human use.
Receptor
Others

Chemical Information

Kurarinone

(2S)-(-)-kurarinone is a trihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7, 2' and 4', a lavandulyl group at position 8 and a methoxy group at position 5. Isolated from the roots of Sophora flavescens, it exhibits cytotoxicity against human myeloid leukemia HL-60 cells. It has a role as a metabolite and an antineoplastic agent. It is a member of 4'-hydroxyflavanones, a monomethoxyflavanone and a trihydroxyflavanone. It is functionally related to a (2S)-flavanone.

CAS Number34981-26-5
PubChem CID11982640
IUPAC Name(2S)-2-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one
Molecular FormulaC26H30O6
Molecular Weight438.5
XLogP5.6
Topological Polar Surface Area96.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity698
SMILES
CC(=CC[C@H](CC1=C2C(=C(C=C1O)OC)C(=O)C[C@H](O2)C3=C(C=C(C=C3)O)O)C(=C)C)C
InChI
InChI=1S/C26H30O6/c1-14(2)6-7-16(15(3)4)10-19-21(29)12-24(31-5)25-22(30)13-23(32-26(19)25)18-9-8-17(27)11-20(18)28/h6,8-9,11-12,16,23,27-29H,3,7,10,13H2,1-2,4-5H3/t16-,23+/m1/s1
InChIKey
LTTQKYMNTNISSZ-MWTRTKDXSA-N
Chemical Structure
2D Structure
2D structure of Kurarinone
CAS: 34981-26-5
CID: 11982640
Formula: C26H30O6
MW: 438.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight438.5
XLogP35.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass438.20423867
Monoisotopic Mass438.20423867
Topological Polar Surface Area96.2 Ų
Heavy Atom Count32
Formal Charge0
Complexity698
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
M31175-01Kuraridine

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CatalogName
576883Kurarinone
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371628Kurarinone discontinued
371732Nor-kurarinone discontinued
371629Kurarinone, 2'-O-methyl- discontinued
AB11882'-O-methyl-Kurarinone
300536Kurarinone, 2'-O-methyl-

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