BOT-64

• Description :

  BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compoundBOT-64 inhibits IKKbeta-mediated IkappaBalpha phosphorylation in LPS-activated macrophages, resulting in sequential prevention of downstream events, including proteolytic degradation of IkappaBalpha, DNA binding ability, and transcriptional activity of NF-kappaB.

• Stability :

  ≥ 2 years

• Purity :

  >98% (HPLC)

• Weight :

  273.35

• Molecular Formula :

  C15H15NO2S

• Notes :

  Research use only, not for human use.

• Receptor :

  IKK2

• CAS Number :

  113760-29-5