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Duvoglustat hydrochloride

CAT: 1410-M22641-01Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M22641-01Size:1 mL x 10 mM in DMSO
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Description
Duvoglustat is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.
CAS Number
73285-50-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
199.63
Molecular Formula
C6H14ClNO4
Notes
Research use only, not for human use.
Receptor
Α-glucosidase

Chemical Information

1-Deoxynojirimycin Hydrochloride

AT2220 is an experimental, oral therapy for the treatment of Pompe disease and belongs to a class of molecules known as pharmacological chaperones. It is a small molecule designed to act as a pharmacological chaperone that specifically binds, stabilizes, and facilitates the proper folding and trafficking of α-glucosidase (GAA). GAA to the lysosome, where it can perform its normal function. AT2220 has been shown to increase GAA activity in cell lines derived from Pompe patients and in transfected cells expressing misfolded forms of GAA.

CAS Number73285-50-4
PubChem CID13018787
IUPAC Name(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol;hydrochloride
Molecular FormulaC6H14ClNO4
Molecular Weight199.63
Topological Polar Surface Area93
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count12
Formal Charge0
Complexity132
SMILES
C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O.Cl
InChI
InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/m1./s1
InChIKey
ZJIHMALTJRDNQI-VFQQELCFSA-N
Chemical Structure
2D Structure
2D structure of 1-Deoxynojirimycin Hydrochloride
CAS: 73285-50-4
CID: 13018787
Formula: C6H14ClNO4
MW: 199.63
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight199.63
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass199.0611356
Monoisotopic Mass199.0611356
Topological Polar Surface Area93 Ų
Heavy Atom Count12
Formal Charge0
Complexity132
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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