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CB-103

CAT: 1410-M22609-01Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M22609-01Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity. CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines, and exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines.
CAS Number
218457-67-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
242.32
Molecular Formula
C15H18N2O
Notes
Research use only, not for human use.
Receptor
Notch

Chemical Information

Cb-103

CB-103 is an organic molecular entity. It has a role as an inhibitor and an antineoplastic agent.

CAS Number218457-67-1
PubChem CID2735289
IUPAC Name6-(4-tert-butylphenoxy)pyridin-3-amine
Molecular FormulaC15H18N2O
Molecular Weight242.32
XLogP3.7
Topological Polar Surface Area48.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count18
Formal Charge0
Complexity254
SMILES
CC(C)(C)C1=CC=C(C=C1)OC2=NC=C(C=C2)N
InChI
InChI=1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3
InChIKey
WHIWGRCYMQLLAO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cb-103
CAS: 218457-67-1
CID: 2735289
Formula: C15H18N2O
MW: 242.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight242.32
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass242.141913202
Monoisotopic Mass242.141913202
Topological Polar Surface Area48.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity254
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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