ML-180

• Description :

  ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 µM) .ML-180 (0.5-5 µM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 µM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling.

• Stability :

  ≥ 2 years

• Purity :

  >98% (HPLC)

• Weight :

  388.89

• Molecular Formula :

  C20H25ClN4O2

• Notes :

  Research use only, not for human use.

• Receptor :

  Orphan nuclear receptor NR5A2

• CAS Number :

  863588-32-3