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ML-180

CAT: 1410-M22607-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:1410-M22607-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 µM) .ML-180 (0.5-5 µM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 µM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling.
CAS Number
863588-32-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
388.89
Molecular Formula
C20H25ClN4O2
Notes
Research use only, not for human use.
Receptor
Orphan nuclear receptor NR5A2

Chemical Information

SR1848

6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione is a member of piperazines.

CAS Number863588-32-3
PubChem CID3238389
IUPAC Name6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione
Molecular FormulaC20H25ClN4O2
Molecular Weight388.9
XLogP3.6
Topological Polar Surface Area55.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity597
SMILES
C1CCC(CC1)N2C(=O)C=C(NC2=O)N3CCN(CC3)C4=CC(=CC=C4)Cl
InChI
InChI=1S/C20H25ClN4O2/c21-15-5-4-8-17(13-15)23-9-11-24(12-10-23)18-14-19(26)25(20(27)22-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,22,27)
InChIKey
CHMQQIFPOIZPIJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SR1848
CAS: 863588-32-3
CID: 3238389
Formula: C20H25ClN4O2
MW: 388.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight388.9
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass388.1666037
Monoisotopic Mass388.1666037
Topological Polar Surface Area55.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity597
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
T12075-01ML-180
A22701-50ML-180 50mg
A22701-5ML-180 5mg
A22701-10ML-180 10mg
A22701-100ML-180 100mg
A22701-25ML-180 25mg
A22701-2ML-180 2mg
A22701-1ML-180 1mg
A22701-10mM-DML-180 10mM * 1mL in DMSO
D2004-3-180Solution 3 Neutralizing Buffer (180 mL)

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