ML-180

• Description:

  ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 µM) .ML-180 (0.5-5 µM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 µM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  388.89

• Molecular Formula:

  C20H25ClN4O2

• Notes:

  Research use only, not for human use.

• Receptor:

  Orphan nuclear receptor NR5A2

• CAS Number:

  863588-32-3