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Pyr10

CAT: 1410-M22464-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M22464-07Size:100 mg
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Description
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1) /Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) (IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells) .
CAS Number
1315323-00-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
449.37
Molecular Formula
C18H13F6N3O2S
Notes
Research use only, not for human use.
Receptor
TRPC3

Chemical Information

TPRC3 Channel Inhibitor III, Pyr10
CAS Number1315323-00-2
PubChem CID53475435
IUPAC NameN-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide
Molecular FormulaC18H13F6N3O2S
Molecular Weight449.4
XLogP4.6
Topological Polar Surface Area72.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity678
SMILES
CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C18H13F6N3O2S/c1-11-2-8-14(9-3-11)30(28,29)26-12-4-6-13(7-5-12)27-16(18(22,23)24)10-15(25-27)17(19,20)21/h2-10,26H,1H3
InChIKey
CVALMMCIOLXHDM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of TPRC3 Channel Inhibitor III, Pyr10
CAS: 1315323-00-2
CID: 53475435
Formula: C18H13F6N3O2S
MW: 449.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight449.4
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass449.06326681
Monoisotopic Mass449.06326681
Topological Polar Surface Area72.4 Ų
Heavy Atom Count30
Formal Charge0
Complexity678
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
QCC32300-01Pyr10
A20786-25Pyr10 25mg
A20786-100Pyr10 100mg
A20786-50Pyr10 50mg
A20786-10Pyr10 10mg
A20786-5Pyr10 5mg
A20786-10mM-DPyr10 10mM * 1mL in DMSO
217850TRPC3 Channel Inhibitor III, Pyr10 (N- (4- (3,5-bis (trifluoromethyl) -1H-pyrazol-1-yl) phenyl) -4-methylbenzenesulfonamide)

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