Products for Research Use Only
RegisterLogin

Verubulin hydrochloride

CAT: 1410-M22453-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1410-M22453-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Verubulin hydrochloride is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities, with potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models.
CAS Number
917369-31-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
315.8
Molecular Formula
C17H18ClN3O
Notes
Research use only, not for human use.
Receptor
Microtubule

Chemical Information

Verubulin Hydrochloride

Verubulin Hydrochloride is the hydrochloride salt form of verubulin, a quinazoline derivative with potential dual antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors that express these transporters. In addition, as a vascular disrupting agent (VDA), verubulin appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death.

CAS Number917369-31-4
PubChem CID11638255
IUPAC NameN-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine;hydrochloride
Molecular FormulaC17H18ClN3O
Molecular Weight315.8
Topological Polar Surface Area38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity330
SMILES
CC1=NC2=CC=CC=C2C(=N1)N(C)C3=CC=C(C=C3)OC.Cl
InChI
InChI=1S/C17H17N3O.ClH/c1-12-18-16-7-5-4-6-15(16)17(19-12)20(2)13-8-10-14(21-3)11-9-13;/h4-11H,1-3H3;1H
InChIKey
VYUWDIKZJLOZJL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Verubulin Hydrochloride
CAS: 917369-31-4
CID: 11638255
Formula: C17H18ClN3O
MW: 315.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight315.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass315.1138399
Monoisotopic Mass315.1138399
Topological Polar Surface Area38.3 Ų
Heavy Atom Count22
Formal Charge0
Complexity330
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
M33530-01Verubulin
M15709-01Mitoxantrone hydrochloride
M15563-01Thiamine hydrochloride
M15453-01Chlorprothixene hydrochloride
M15431-01Amodiaquine hydrochloride
M15414-01Betaxolol hydrochloride
M15335-01Phenylephrine hydrochloride
M15332-01Chloropyramine hydrochloride
M15300-01Methoxamine hydrochloride
M15298-01Dibucaine hydrochloride

Alternative Products

CatalogName
HY-12098-01Verubulin (hydrochloride)
T13298-01Verubulin hydrochloride
A21607-100Verubulin hydrochloride 100mg
A21607-25Verubulin hydrochloride 25mg
HY-12098RVerubulin (hydrochloride) (Standard)
A21607-1Verubulin hydrochloride 1mg
A21607-200Verubulin hydrochloride 200mg
A21607-50Verubulin hydrochloride 50mg
A21607-5Verubulin hydrochloride 5mg
A21607-10Verubulin hydrochloride 10mg

Popular Products