AV-412

• Description:

  AV-412 is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM) .In cells, MP-412 inhibited autophosphorylation of EGFR and ErbB2 with IC (50) of 43 and 282 nM, respectively.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  851.41

• Molecular Formula:

  C41H44ClFN6O7S2

• Notes:

  Research use only, not for human use.

• Receptor:

  EGFR|EGFR (L858R) |EGFR (T790M) |EGFR (L858R/T790M) |ErbB2

• CAS Number:

  451493-31-5