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SC-43

CAT: 1410-M22110-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M22110-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6) . SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.SC-43, a sorafenib derivative.
CAS Number
1400989-25-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
431.8
Molecular Formula
C21H13ClF3N3O2
Notes
Research use only, not for human use.
Receptor
SHP-1|STAT3|apoptosis

Chemical Information

Sc-43

SHP-1 Agonist SC-43 is an orally available, small molecule agonist of Src homology region 2 domain-containing phosphatase-1 (SHP-1; tyrosine-protein phosphatase non-receptor type 6; PTPN6) with potential antineoplastic activity. Upon administration, SHP-1 agonist SC-43 enhances SHP-1 activity by impairing the association between the N-terminal Src homology 2 (N-SH2) domain and the protein tyrosine phosphatase (PTP) domain of SHP-1, triggering a conformational change of SHP-1 and relieving its autoinhibition. Activation of SHP-1 represses signal transducer and activator of transcription 3 (STAT3) signaling by inhibiting constitutive and interleukin-6 (IL-6)-induced STAT3 phosphorylation. The STAT3 pathway is overly active in many cancer types and is implicated in cancer stem cell-mediated growth, recurrence, stemness, and resistance to conventional chemotherapies.

CAS Number1400989-25-4
PubChem CID70688629
IUPAC Name1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[3-(4-cyanophenoxy)phenyl]urea
Molecular FormulaC21H13ClF3N3O2
Molecular Weight431.8
XLogP6
Topological Polar Surface Area74.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity631
SMILES
C1=CC(=CC(=C1)OC2=CC=C(C=C2)C#N)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
InChI
InChI=1S/C21H13ClF3N3O2/c22-19-9-6-15(11-18(19)21(23,24)25)28-20(29)27-14-2-1-3-17(10-14)30-16-7-4-13(12-26)5-8-16/h1-11H,(H2,27,28,29)
InChIKey
QIBWSQJZKMUZAK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sc-43
CAS: 1400989-25-4
CID: 70688629
Formula: C21H13ClF3N3O2
MW: 431.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight431.8
XLogP36
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass431.0648388
Monoisotopic Mass431.0648388
Topological Polar Surface Area74.2 Ų
Heavy Atom Count30
Formal Charge0
Complexity631
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA2806-1SC-43
A22295-100SC-43 100mg
A22295-50SC-43 50mg
A22295-1SC-43 1mg
A22295-10SC-43 10mg
A22295-5SC-43 5mg
A22295-25SC-43 25mg
A22295-10mM-DSC-43 10mM * 1mL in DMSO
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