R1487

CAT: 1410-M20961-01Size: 1 EachDry Ice: NoHazardous: No

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CAT#:1410-M20961-01Size:1 Each

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Description

R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.

CAS Number

449811-92-1

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

388.36

Molecular Formula

C19H18F2N4O3

Notes

Research use only, not for human use.

Receptor

P38α

Chemical Information

R-1487

CAS Number	449811-92-1
PubChem CID	11406590
IUPAC Name	6-(2,4-difluorophenoxy)-8-methyl-2-(oxan-4-ylamino)pyrido[2,3-d]pyrimidin-7-one
Molecular Formula	C19H18F2N4O3
Molecular Weight	388.4
XLogP	2.8
Topological Polar Surface Area	76.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Heavy Atom Count	28
Formal Charge	0
Complexity	602

SMILES

CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC4CCOCC4

InChI

InChI=1S/C19H18F2N4O3/c1-25-17-11(10-22-19(24-17)23-13-4-6-27-7-5-13)8-16(18(25)26)28-15-3-2-12(20)9-14(15)21/h2-3,8-10,13H,4-7H2,1H3,(H,22,23,24)

InChIKey

KKKRKRMVJRHDMG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 449811-92-1

CID: 11406590

Formula: C19H18F2N4O3

MW: 388.4

Interactive 3D Structure

Loading 3D structure...

Computed Properties

Property	Value
Molecular Weight	388.4
XLogP3	2.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	388.13469677
Monoisotopic Mass	388.13469677
Topological Polar Surface Area	76.6 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	602
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes