Hexamethylene amiloride

• Description:

  HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM) . It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for various NHE isoforms.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  311.77

• Molecular Formula:

  C12H18ClN7O

• Notes:

  Research use only, not for human use.

• Receptor:

  NHE exchangers| TRPA1| ASIC3| P2X7

• CAS Number:

  1428-95-1