C188-9

Chemical Information
STAT3 Inhibitor C-188-9 is an orally bioavailable, binaphthol-sulfonamide-based inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. Upon oral administration, the STAT3 inhibitor C-188-9 specifically targets and binds to the phosphotyrosyl peptide binding site within the Src homology 2 (SH2) domain of STAT3. This inhibits the Janus kinase (JAK)-mediated tyrosine phosphorylation and activation of STAT3. This impedes nuclear translocation of STAT3, prevents STAT3 binding to responsive gene promoters and blocks STAT3-mediated regulation of gene expression. STAT3 regulates the transcription of genes involved in several cellular functions. STAT3 is constitutively activated in a variety of human cancers and plays a key role in neoplastic transformation, uncontrolled tumor cell proliferation, resistance to apoptosis, metastasis, immune evasion, tumor angiogenesis, epithelial-mesenchymal transition (EMT) and the Warburg effect.
| CAS Number | 432001-19-9 |
| PubChem CID | 1324494 |
| IUPAC Name | N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)naphthalen-1-yl]-4-methoxybenzenesulfonamide |
| Molecular Formula | C27H21NO5S |
| Molecular Weight | 471.5 |
| XLogP | 5.8 |
| Topological Polar Surface Area | 104 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Heavy Atom Count | 34 |
| Formal Charge | 0 |
| Complexity | 776 |
| Property | Value |
|---|---|
| Molecular Weight | 471.5 |
| XLogP3 | 5.8 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 471.11404394 |
| Monoisotopic Mass | 471.11404394 |
| Topological Polar Surface Area | 104 Ų |
| Heavy Atom Count | 34 |
| Formal Charge | 0 |
| Complexity | 776 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Related Products
Alternative Products
| Catalog | Name |
|---|---|
| C13533-01 | C188-9 |
| A16804-2 | C188-9 2mg |
Popular Products

MitoTracker Red CMXRos
SKU: G1723-50UG|Size: 50 μg

Erdafitinib (JNJ-42756493)
SKU: MBS3841281-01|Size: 10 mg

Human Lung Cancer Carcinoma Associated Fibroblasts
SKU: ABC-H0079X|Size: 1 Vial

Human Cancer Associated Fibroblasts (CAF)
SKU: ARP1014|Size: 1 Million

Human Lung Squamous Cell Tumor Carcinoma Associated Fibroblasts
SKU: ABC-TC5540|Size: 1 Vial

Tungsten Oxide
SKU: IN12270|Size: 1 Each

Round Snap Lock Containers x 500
SKU: RSL-500|Size: 500 Each

FNC Coating Mix®, 100 ml
SKU: 0407|Size: 100 mL

Mouse Sulfatase 2 (SULF2) ELISA Kit
SKU: RD-SULF2-Mu-01|Size: 96 Tests

POLI Polyclonal Antibody
SKU: RD89193A-01|Size: 60 μL

Mito-Tracker Red CMXRos
SKU: B8810-.05|Size: 50 µg

Mito-Tracker Green
SKU: B8811-.05|Size: 50 µg

MitoTracker Green FM
SKU: HY-135056|Size: 50 µg

MitoTracker Red CMXRos
SKU: G1723-50UG|Size: 50 μg

MitoTracker®Green FM
SKU: CST 9074S|Size: 500 µg

Mito-Tracker Green
SKU: G1740-50UG|Size: 50 μg

MitoTracker Deep Red FM
SKU: T86902-01|Size: 10 mg

Mito-Tracker Deep Red FM
SKU: C1032-50μg|Size: 50 µg

Mito-Tracker Green
SKU: C1048|Size: 50 µg

MitoTracker Red CMXRos
SKU: M9940-01|Size: 50 µg
