CHF5074

CAT: 1410-M17588-05Size: 50 mgDry Ice: NoHazardous: No

1 / 1

CAT#:1410-M17588-05Size:50 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM) .

CAS Number

749269-83-8

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

325.16

Molecular Formula

C16H11Cl2FO2

Notes

Research use only, not for human use.

Receptor

Beta Amyloid| γ secretase

Chemical Information

Chf-5074

CAS Number	749269-83-8
PubChem CID	9996409
IUPAC Name	1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid
Molecular Formula	C16H11Cl2FO2
Molecular Weight	325.2
XLogP	4.7
Topological Polar Surface Area	37.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	21
Formal Charge	0
Complexity	413

SMILES

C1CC1(C2=CC(=C(C=C2)C3=CC(=C(C=C3)Cl)Cl)F)C(=O)O

InChI

InChI=1S/C16H11Cl2FO2/c17-12-4-1-9(7-13(12)18)11-3-2-10(8-14(11)19)16(5-6-16)15(20)21/h1-4,7-8H,5-6H2,(H,20,21)

InChIKey

LIYLTQQDABRNRX-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 749269-83-8

CID: 9996409

Formula: C16H11Cl2FO2

MW: 325.2

Interactive 3D Structure

Loading 3D structure...

Computed Properties

Property	Value
Molecular Weight	325.2
XLogP3	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	324.0120131
Monoisotopic Mass	324.0120131
Topological Polar Surface Area	37.3 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	413
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes