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OSI-420

CAT: 1410-M17392-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:1410-M17392-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.
CAS Number
183320-51-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
415.87
Molecular Formula
C21H21N3O4·HCl
Notes
Research use only, not for human use.
Receptor
EGFR

Chemical Information

Desmethyl Erlotinib
CAS Number183320-51-6
PubChem CID18924996
IUPAC Name2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol;hydrochloride
Molecular FormulaC21H22ClN3O4
Molecular Weight415.9
Topological Polar Surface Area85.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Heavy Atom Count29
Formal Charge0
Complexity511
SMILES
COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO.Cl
InChI
InChI=1S/C21H21N3O4.ClH/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21;/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24);1H
InChIKey
BUOXOWNQZVIETJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Desmethyl Erlotinib
CAS: 183320-51-6
CID: 18924996
Formula: C21H22ClN3O4
MW: 415.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight415.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Exact Mass415.1298839
Monoisotopic Mass415.1298839
Topological Polar Surface Area85.7 Ų
Heavy Atom Count29
Formal Charge0
Complexity511
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
FO158697-01OSI-420
461655-01OSI 420
A10678-2OSI-420 2mg
A10678-100OSI-420 100mg
A10678-5OSI-420 5mg
A10678-50OSI-420 50mg
A10678-25OSI-420 25mg
A10678-10OSI-420 10mg
A10678-1OSI-420 1mg
B1495-200OSI-420 free base

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