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AHU-377

CAT: 1410-M17325-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M17325-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AHU-377 is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.
CAS Number
149709-62-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
411.49
Molecular Formula
C24H29NO5
Notes
Research use only, not for human use.
Receptor
Neprilysin

Chemical Information

Sacubitril

Sacubitril is a member of biphenyls.

CAS Number149709-62-6
PubChem CID9811834
IUPAC Name4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid
Molecular FormulaC24H29NO5
Molecular Weight411.5
XLogP3.7
Topological Polar Surface Area92.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Heavy Atom Count30
Formal Charge0
Complexity550
SMILES
CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O
InChI
InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1
InChIKey
PYNXFZCZUAOOQC-UTKZUKDTSA-N
Chemical Structure
2D Structure
2D structure of Sacubitril
CAS: 149709-62-6
CID: 9811834
Formula: C24H29NO5
MW: 411.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight411.5
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Exact Mass411.20457303
Monoisotopic Mass411.20457303
Topological Polar Surface Area92.7 Ų
Heavy Atom Count30
Formal Charge0
Complexity550
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
9520-5AHU-377
sc-492600AHU 377
A13682-25AHU-377 25mg
B1070-5.1AHU-377(Sacubitril)
A13682-10AHU-377 10mg
TMIH-0076-01AHU-377-d4
A13682-5AHU-377 5mg
GTR19153681-01AHU-377 (LCZ696)
B3267-10AHU-377 hemicalcium salt
MBS384159-01AHU-377 (Sacubitril calcium)

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