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Ladarixin

CAT: 1410-M16169-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M16169-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A novel allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM.
CAS Number
849776-05-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
375.333
Molecular Formula
C11H12F3NO6S2
Notes
Research use only, not for human use.
Receptor
Chemokine Receptor

Chemical Information

Ladarixin

Ladarixin is under investigation in clinical trial NCT04628481 (A Study of Oral Ladarixin in New-onset Type 1 Diabetes and a Low Residual Β-Cell Function).

CAS Number849776-05-2
PubChem CID11372270
IUPAC Name[4-[(2R)-1-(methanesulfonamido)-1-oxopropan-2-yl]phenyl] trifluoromethanesulfonate
Molecular FormulaC11H12F3NO6S2
Molecular Weight375.3
XLogP2
Topological Polar Surface Area123
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity624
SMILES
C[C@H](C1=CC=C(C=C1)OS(=O)(=O)C(F)(F)F)C(=O)NS(=O)(=O)C
InChI
InChI=1S/C11H12F3NO6S2/c1-7(10(16)15-22(2,17)18)8-3-5-9(6-4-8)21-23(19,20)11(12,13)14/h3-7H,1-2H3,(H,15,16)/t7-/m1/s1
InChIKey
DDLPYOCJHQSVSZ-SSDOTTSWSA-N
Chemical Structure
2D Structure
2D structure of Ladarixin
CAS: 849776-05-2
CID: 11372270
Formula: C11H12F3NO6S2
MW: 375.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight375.3
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass375.00581394
Monoisotopic Mass375.00581394
Topological Polar Surface Area123 Ų
Heavy Atom Count23
Formal Charge0
Complexity624
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19264851-01Ladarixin
MBS5777496Ladarixin sodium
HY-19519A-01Ladarixin (sodium)
A24308-100Ladarixin (DF 2156A free base) 100mg
A24308-50Ladarixin (DF 2156A free base) 50mg
A24308-5Ladarixin (DF 2156A free base) 5mg

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