PHA-848125

• Description:

  A potent, selective, brain penetrant and orally available dual CDK and TRK inhibitor with IC50 of 45 and 53 nM for CDK2/cyclin A and TrkA, respectively; shows cross-reactivity with other CDKs (CDK1/4/5/7), TrkB/C, Kit, Abl and PDGFR (IC50s<1 uM) .

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  460.5746

• Molecular Formula:

  C25H32N8O

• Notes:

  Research use only, not for human use.

• Receptor:

  CDK2/CyclinA| CDK4/CyclinD1| CDK5/p35| CDK7/CyclinH| TrkA

• CAS Number:

  802539-81-7