PHA-848125

• Description :

  A potent, selective, brain penetrant and orally available dual CDK and TRK inhibitor with IC50 of 45 and 53 nM for CDK2/cyclin A and TrkA, respectively; shows cross-reactivity with other CDKs (CDK1/4/5/7), TrkB/C, Kit, Abl and PDGFR (IC50s<1 uM) .

• Stability :

  ≥ 2 years

• Purity :

  >98% (HPLC)

• Weight :

  460.5746

• Molecular Formula :

  C25H32N8O

• Notes :

  Research use only, not for human use.

• Receptor :

  CDK2/CyclinA| CDK4/CyclinD1| CDK5/p35| CDK7/CyclinH| TrkA

• CAS Number :

  802539-81-7